Volume 6, Issue 5, September 2020, Page: 61-66
Safety Issues Associated with Paclitaxel-Eluting Balloons and Progress of Sirolimus-Eluting Balloons
Yu Xia Yin, National United Engineering Laboratory for Biomedical Material Modification, Dezhou, China; School of Materials Science and Engineering, University of Science and Technology, Beijing, China
Zhi Yong Wang, Department of Emergency, Inner Mongolia people's Hospital, Hohhot, China
Lu Ning Wang, School of Materials Science and Engineering, University of Science and Technology, Beijing, China
Ming Kun Cao, National United Engineering Laboratory for Biomedical Material Modification, Dezhou, China
Tian Heng Lu, National United Engineering Laboratory for Biomedical Material Modification, Dezhou, China
Hai Jun Zhang, National United Engineering Laboratory for Biomedical Material Modification, Dezhou, China; Department of Vascular & Intervention, Tenth Peoples' Hospital of Tongji University, Shanghai, China; Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark
Received: Feb. 1, 2020;       Accepted: Sep. 14, 2020;       Published: Sep. 19, 2020
DOI: 10.11648/j.ijcts.20200605.11      View  50      Downloads  24
Abstract
Drug eluting balloons (DEBs) are semi-compliant angioplasty balloons covered with an antiproliferative drug which is rapidly released locally into the vessel wall during balloon contact. Their advantages include a broader area of drug contact, more homogenous drug-tissue transfer for stent-based local drug delivery, no implant leaving as well as shortened dual antiplatelet therapy. DEBs application was first recommended by the European Society of Cardiology (ESC) and European Association for Cardio-Thoracic Surgery (EACTS) guidelines for the treatment of in-stent restenosis (ISR) after prior bare-metal stent (BMS) (Class IIA, Level B) in 2010. Since then, rapid progress has been made in the use of DEBs for treatment of in-stent restenosis, bifurcation, small vessel diseases, and other de novo occlusive coronary artery diseases even the symptomatic peripheral arterial disease. However, a meta-analysis of 28 randomized controlled trials (RCTs) with 4663 patients investigating paclitaxel-coated devices (DEBs & drug-eluting stent) in the femoral and/or popliteal arteries showed a highly significant association between risk of death and paclitaxel exposure in a dose-time-dependent manner. Safety issues associated with clinical application of paclitaxel DEBs in femoropopliteal artery was widely discussed. This study reviewed the issues, different molecular mechanisms of paclitaxel and sirolimus in antiproliferative effects, and progress of sirolimus-eluting balloons.
Keywords
Drug Eluting Balloons, Paclitaxel-Eluting Balloons, Sirolimus-Eluting Balloons
To cite this article
Yu Xia Yin, Zhi Yong Wang, Lu Ning Wang, Ming Kun Cao, Tian Heng Lu, Hai Jun Zhang, Safety Issues Associated with Paclitaxel-Eluting Balloons and Progress of Sirolimus-Eluting Balloons, International Journal of Cardiovascular and Thoracic Surgery. Vol. 6, No. 5, 2020, pp. 61-66. doi: 10.11648/j.ijcts.20200605.11
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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