Esophageal Gastrointestinal Stromal Tumour: A Case Report
Antonello Cuttitta,
Antonio Tancredi,
Roberto Scaramuzzi,
Paola Parente,
Gerardo Scaramuzzi,
Marco Taurchini
Issue:
Volume 2, Issue 1, May 2016
Pages:
1-4
Received:
30 December 2015
Accepted:
29 February 2016
Published:
5 May 2016
DOI:
10.11648/j.ijcts.20160201.11
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Abstract: Gastrointestinal stromal tumours (GISTs) represent 0.1-3% of all neoplasms of the digestive tract and only in 1-2% of cases they arise in the esophagus. The most frequent clinical manifestations of esophageal GISTs (E-GISTs) are dysphagia, atypical chest pain, cough or gastrointestinal bleeding. Preoperative study is made by endoscopy, echo-endoscopy, biopsy and computed tomography or magnetic resonance imaging. The preoperative diagnosis is difficult because only histological examination can differentiate them from other esophageal tumours (as leiomyoma, schwannoma and leiomyosarcoma) and rarely a biopsy is performed at a submucosal well-circumscribed esophageal mass. Surgery is the first choice approach for localized and resectable cases. Thoracoscopic or laparoscopic enucleation is sufficient for small-sized and well-capsulated tumours, instead, esophagectomy should be considered in all other cases. Imatinib is the drug of choice for pharmacologic treatment in advanced disease. We report our anecdotal experience of a 63-year old male patient presented at our Unit complaining of dysphagia and underwent transhiatal laparoscopic enucleation of E-GIST.
Abstract: Gastrointestinal stromal tumours (GISTs) represent 0.1-3% of all neoplasms of the digestive tract and only in 1-2% of cases they arise in the esophagus. The most frequent clinical manifestations of esophageal GISTs (E-GISTs) are dysphagia, atypical chest pain, cough or gastrointestinal bleeding. Preoperative study is made by endoscopy, echo-endosco...
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Solitary Extramedullary Plasmacytoma of the Trachea: A Case Report
Antonello Cuttitta,
Antonio Tancredi,
Roberto Scaramuzzi,
Antonietta Falcone,
Gerardo Scaramuzzi,
Marco Taurchini
Issue:
Volume 2, Issue 1, May 2016
Pages:
5-8
Received:
30 December 2015
Accepted:
29 February 2016
Published:
5 May 2016
DOI:
10.11648/j.ijcts.20160201.12
Downloads:
Views:
Abstract: The extramedullary plasmacytomas is a plasma cell tumour arising outside the bone marrow and constitutes around 4 % of all plasma cell neoplasms. The Extramedullary Plasmacytoma of the Trachea (EPT) is an extremely rare condition and presents as a tracheal expanding mass. The most common symptoms consist of coughing, dyspnoea, voice change, stridor and expiratory wheezing. The diagnosis is done by computed tomography, bronchoscopy and histological examination which demonstrates neoplastic monoclonal plasma cells expressing specific antigens. The treatment of the EPT remains still speculative, current options are radiotherapy or surgery alone and surgery followed by radiotherapy. The adjuvant chemotherapy is considered only in case of relapse or systemic spread. The prognosis is comforting: the complete remission occurs in 60 % of cases, the recurrence in 22 %, the progression to multiple myeloma in 16 %. We report the case of a 51-year-old female affected by EPT and treated with the removal of the first four tracheal rings and subsequent PAD chemotherapy (bortezomib, adriamycin and dexamethasone). Although the stage of the tumour was early, we decided to administer chemotherapy conceiving it as a preventive systemic treatment.
Abstract: The extramedullary plasmacytomas is a plasma cell tumour arising outside the bone marrow and constitutes around 4 % of all plasma cell neoplasms. The Extramedullary Plasmacytoma of the Trachea (EPT) is an extremely rare condition and presents as a tracheal expanding mass. The most common symptoms consist of coughing, dyspnoea, voice change, stridor...
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