Determination of Antiphospholipid Antibody Levels Among Patients with Acute Myocardial Infraction in Khartoum State (Time)
Mohamed Hilmi,
Ehab Mohamed,
Albara Ahmed,
Sahar Elderdiri Gafar Osman
Issue:
Volume 7, Issue 5, September 2021
Pages:
50-54
Received:
26 May 2021
Accepted:
17 June 2021
Published:
12 October 2021
Abstract: Background: Antiphospholipid antibodies (Anti PLP Antibody) are a group of autoimmune antibodies that targeting an individual's own proteins in an autoimmune response against phospholipids. Which released from plasma membrane to make prothrombinase complex and provide suitable environment for biological activity. In Antiphospholipid syndrome anti PLP antibodies attacks phospholipid in surface of plasma membrane and release PLP into the circulation which can activate coagulation cascade and form thrombi that leads to myocardial infraction (MI). Objectives: The current study was aimed to assess the antiphospholipid antibodies among patients with acute myocardial infraction in Khartoum state 2021 and compared to normal adult healthy control. Methods: An analytical case and control study was conducted in Yastapshiron hospital lab in Khartoum states laboratory in the period from from October 2020 to January 2021 on a total of 50 patients with acute MI (according to protocol/criteria/ scoring systrm,…) as case group and compared with another 50 healthy adults as control group, for both groups serum antiphospholipid was assessed using ELISA manual (AESKU), data were collected and then analyzed using SPssDD version. Result: from the study; the gender distribution was 35 male and 15 female among case group with age of 61.1 year. Among case group; 3 patients (6%) showed positive antiphospholipid while the remaining 47 (94%) was negative, the antiphospholipid antibodies mean concentration was significantly higher among case compared to the control 0.293±0.17 and 0.226±0.15 (unit) respectively, P.value was 0.042. It was found space in age the lowest age was 35 and highest age was 94 and the correlation was 0.154.
Abstract: Background: Antiphospholipid antibodies (Anti PLP Antibody) are a group of autoimmune antibodies that targeting an individual's own proteins in an autoimmune response against phospholipids. Which released from plasma membrane to make prothrombinase complex and provide suitable environment for biological activity. In Antiphospholipid syndrome anti P...
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Implantation Strategies to Protect the Total Artificial Heart for Subsequent Heart Transplantation
Kai Ihnken,
Francisco Arabia
Issue:
Volume 7, Issue 5, September 2021
Pages:
55-58
Received:
29 August 2021
Accepted:
26 September 2021
Published:
12 October 2021
Abstract: Re-entry into the chest after one or more previous operative interventions can result in prolonged dissection, blood loss, structural damage, and catastrophic injuries, resulting in MOF and even death. Previous implantation of mechanical circulatory assist devices may lead to development of dense adhesions and solid scar tissue. This is certainly true for cases involving previous placement of the total artificial heart (TAH). Implantation of this device is on the rise, as is it is the only viable options for patients with biventricular failure, as the number of heart transplantations is stagnant worldwide. With the new heart transplantation allocation system in the United States, more and more patients with an implanted TAH are waiting for cardiac transplantation. Therefore, patients having an implanted TAH presenting for transplantation are at risk for complications during sternal re-entry or for complications as a result of prolonged ischemic time due to extended times of mediastinal dissection. Thoughtful and preemptive preparation of the surgical field at the time of initial implantation of the TAH has not only the potential, but a proven track record of decreasing operative time, duration of mediastinal dissection as well as risks for complications and adverse events in patients with subsequent heart transplantation. In conclusion, the measures for TAH protection taken at the time of implantation allow for expeditious and safe redo sternotomy, efficient mediastinal dissection, rapid identification and exposure of structures necessary for initiation of cardiopulmonary bypass and finally and importantly expeditious device removal in order to avoid delay in donor organ implantation and prolonged ischemic time.
Abstract: Re-entry into the chest after one or more previous operative interventions can result in prolonged dissection, blood loss, structural damage, and catastrophic injuries, resulting in MOF and even death. Previous implantation of mechanical circulatory assist devices may lead to development of dense adhesions and solid scar tissue. This is certainly t...
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